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Rheumatoid Factor Positivity Is Associated with Increased Joint Destruction and Upregulation of Matrix Metalloproteinase 9 and Cathepsin K Gene Expression in the Peripheral Blood in Rheumatoid Arthritic Patients Treated with Methotrexate
المؤلفون المشاركون
Demidova, Natalia V.
Karateev, Dmitry E.
Tchetina, Elena V.
Nasonov, Eugeny L.
المصدر
International Journal of Rheumatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We evaluated changes in gene expression of mTOR, p21, caspase-3, ULK1, TNFα, matrix metalloproteinase (MMP)-9, and cathepsin K in the whole blood of rheumatoid arthritic (RA) patients treated with methotrexate (MTX) in relation to their rheumatoid factor status, clinical, immunological, and radiological parameters, and therapeutic response after a 24-month follow-up.
The study group consisted of 35 control subjects and 33 RA patients without previous history of MTX treatment.
Gene expression was measured using real-time RT-PCR.
Decreased disease activity in patients at the end of the study was associated with significant downregulation of TNFα expression.
Downregulation of mTOR was observed in seronegative patients, while no significant changes in the expression of p21, ULK1, or caspase-3 were noted in any RA patients at the end of the study.
The increase in erosion numbers observed in the seropositive patients at the end of the follow-up was accompanied by upregulation of MMP-9 and cathepsin K, while seronegative patients demonstrated an absence of significant changes in MMP-9 and cathepsin K expression and no increase in the erosion score.
Our results suggest that increased expression of MMP-9 and cathepsin K genes in the peripheral blood might indicate higher bone tissue destruction activity in RA patients treated with methotrexate.
The clinical study registration number is 0120.0810610.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tchetina, Elena V.& Demidova, Natalia V.& Karateev, Dmitry E.& Nasonov, Eugeny L.. 2013. Rheumatoid Factor Positivity Is Associated with Increased Joint Destruction and Upregulation of Matrix Metalloproteinase 9 and Cathepsin K Gene Expression in the Peripheral Blood in Rheumatoid Arthritic Patients Treated with Methotrexate. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-473072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tchetina, Elena V.…[et al.]. Rheumatoid Factor Positivity Is Associated with Increased Joint Destruction and Upregulation of Matrix Metalloproteinase 9 and Cathepsin K Gene Expression in the Peripheral Blood in Rheumatoid Arthritic Patients Treated with Methotrexate. International Journal of Rheumatology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-473072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tchetina, Elena V.& Demidova, Natalia V.& Karateev, Dmitry E.& Nasonov, Eugeny L.. Rheumatoid Factor Positivity Is Associated with Increased Joint Destruction and Upregulation of Matrix Metalloproteinase 9 and Cathepsin K Gene Expression in the Peripheral Blood in Rheumatoid Arthritic Patients Treated with Methotrexate. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-473072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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