Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects
المؤلفون المشاركون
Aschauer, Stefan
Weisshaar, Stefan
Doberer, Daniel
Gouya, Ghazaleh
Wolzt, Michael
Storka, Angela
Klickovic, Uros
Bilban, Martin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Heme oxygenase-1 (HO-1) has been proposed to exert pharmacological benefits by its antioxidative and anti-inflammatory effects.
HO-1 expression may be affected by the GT length polymorphism in the promoter region of the HO-1 gene.
We investigated the inducibility of HO-1 by orally administered curcumin in healthy male subjects and its correlation with the GT length polymorphism.
Methods.
In an open label uncontrolled phase-1 pilot study, ten male subjects received 12 g of oral curcumin.
To investigate the effects of the GT length polymorphism on the inducibility of HO-1, five subjects with homozygous short and five with homozygous long GT genotypes were studied.
Plasma concentrations of curcumin, bilirubin, HO-1 mRNA, and protein expression in peripheral blood mononuclear cells (PBMCs) were analyzed over 48 hours.
Results.
At a detection limit of 1 µg/mL curcumin could not be detected in plasma of any subject.
Compared to baseline, HO-1 mRNA and protein levels were not induced in PBMCs at any time point up to 48 hours.
There was no correlation between any of the parameters and GT length polymorphism.
Conclusions.
Oral curcumin administration has low bioavailability and does not induce HO-1 on mRNA or protein level in PBMCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klickovic, Uros& Doberer, Daniel& Gouya, Ghazaleh& Aschauer, Stefan& Weisshaar, Stefan& Storka, Angela…[et al.]. 2014. Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473138
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klickovic, Uros…[et al.]. Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-473138
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klickovic, Uros& Doberer, Daniel& Gouya, Ghazaleh& Aschauer, Stefan& Weisshaar, Stefan& Storka, Angela…[et al.]. Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473138
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473138
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر