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Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects
Joint Authors
Aschauer, Stefan
Weisshaar, Stefan
Doberer, Daniel
Gouya, Ghazaleh
Wolzt, Michael
Storka, Angela
Klickovic, Uros
Bilban, Martin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Heme oxygenase-1 (HO-1) has been proposed to exert pharmacological benefits by its antioxidative and anti-inflammatory effects.
HO-1 expression may be affected by the GT length polymorphism in the promoter region of the HO-1 gene.
We investigated the inducibility of HO-1 by orally administered curcumin in healthy male subjects and its correlation with the GT length polymorphism.
Methods.
In an open label uncontrolled phase-1 pilot study, ten male subjects received 12 g of oral curcumin.
To investigate the effects of the GT length polymorphism on the inducibility of HO-1, five subjects with homozygous short and five with homozygous long GT genotypes were studied.
Plasma concentrations of curcumin, bilirubin, HO-1 mRNA, and protein expression in peripheral blood mononuclear cells (PBMCs) were analyzed over 48 hours.
Results.
At a detection limit of 1 µg/mL curcumin could not be detected in plasma of any subject.
Compared to baseline, HO-1 mRNA and protein levels were not induced in PBMCs at any time point up to 48 hours.
There was no correlation between any of the parameters and GT length polymorphism.
Conclusions.
Oral curcumin administration has low bioavailability and does not induce HO-1 on mRNA or protein level in PBMCs.
American Psychological Association (APA)
Klickovic, Uros& Doberer, Daniel& Gouya, Ghazaleh& Aschauer, Stefan& Weisshaar, Stefan& Storka, Angela…[et al.]. 2014. Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473138
Modern Language Association (MLA)
Klickovic, Uros…[et al.]. Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-473138
American Medical Association (AMA)
Klickovic, Uros& Doberer, Daniel& Gouya, Ghazaleh& Aschauer, Stefan& Weisshaar, Stefan& Storka, Angela…[et al.]. Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473138