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A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway
المؤلفون المشاركون
Tseng, Ching-Ping
Chen, Chuan-Mu
Kao, Shung-Te
Cheng, Ju-Chien
Lin, Hung-Jen
Liao, Mei-Huei
Lin, Chia-Fan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis.
However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear.
In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level.
Moreover, the reactive oxygen species (ROS) were generated in the early stages of mYGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol.
Subsequently, caspase 9 and caspase 3 were activated.
Furthermore, the activation of ER stress-associated caspase 12 in HSCs was also evaluated.
Together, we report the first evidence-based study to demonstrate that mYGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway.
These findings provide rationale for further clinical investigation of traditional Chinese medicine recipes against liver fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Hung-Jen& Tseng, Ching-Ping& Lin, Chia-Fan& Liao, Mei-Huei& Chen, Chuan-Mu& Kao, Shung-Te…[et al.]. 2010. A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Hung-Jen…[et al.]. A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-473236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Hung-Jen& Tseng, Ching-Ping& Lin, Chia-Fan& Liao, Mei-Huei& Chen, Chuan-Mu& Kao, Shung-Te…[et al.]. A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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