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A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway
Joint Authors
Tseng, Ching-Ping
Chen, Chuan-Mu
Kao, Shung-Te
Cheng, Ju-Chien
Lin, Hung-Jen
Liao, Mei-Huei
Lin, Chia-Fan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis.
However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear.
In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level.
Moreover, the reactive oxygen species (ROS) were generated in the early stages of mYGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol.
Subsequently, caspase 9 and caspase 3 were activated.
Furthermore, the activation of ER stress-associated caspase 12 in HSCs was also evaluated.
Together, we report the first evidence-based study to demonstrate that mYGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway.
These findings provide rationale for further clinical investigation of traditional Chinese medicine recipes against liver fibrosis.
American Psychological Association (APA)
Lin, Hung-Jen& Tseng, Ching-Ping& Lin, Chia-Fan& Liao, Mei-Huei& Chen, Chuan-Mu& Kao, Shung-Te…[et al.]. 2010. A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473236
Modern Language Association (MLA)
Lin, Hung-Jen…[et al.]. A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-473236
American Medical Association (AMA)
Lin, Hung-Jen& Tseng, Ching-Ping& Lin, Chia-Fan& Liao, Mei-Huei& Chen, Chuan-Mu& Kao, Shung-Te…[et al.]. A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated MitochondrialCaspase Pathway. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473236