Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin
المؤلفون المشاركون
Melnikov, Valery G.
Manchester, Lucien C.
López-Armas, Gabriela
Tan, Dun Xian
Rosales-Corral, Sergio A.
Cruz-Ramos, J. A.
Reiter, Russel J.
Munoz, Ruben
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Alzheimer pathogenesis involves mitochondrial dysfunction, which is closely related to amyloid-β (Aβ) generation, abnormal tau phosphorylation, oxidative stress, and apoptosis.
Alterations in membranal components, including cholesterol and fatty acids, their characteristics, disposition, and distribution along the membranes, have been studied as evidence of cell membrane alterations in AD brain.
The majority of these studies have been focused on the cytoplasmic membrane; meanwhile the mitochondrial membranes have been less explored.
In this work, we studied lipids and mitochondrial membranes in vivo, following intracerebral injection of fibrillar amyloid-β (Aβ).
The purpose was to determine how Aβ may be responsible for beginning of a vicious cycle where oxidative stress and alterations in cholesterol, lipids and fatty acids, feed back on each other to cause mitochondrial dysfunction.
We observed changes in mitochondrial membrane lipids, and fatty acids, following intracerebral injection of fibrillar Aβ in aged Wistar rats.
Melatonin, a well-known antioxidant and neuroimmunomodulator indoleamine, reversed some of these alterations and protected mitochondrial membranes from obvious damage.
Additionally, melatonin increased the levels of linolenic and n-3 eicosapentaenoic acid, in the same site where amyloid β was injected, favoring an endogenous anti-inflammatory pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rosales-Corral, Sergio A.& López-Armas, Gabriela& Cruz-Ramos, J. A.& Melnikov, Valery G.& Tan, Dun Xian& Manchester, Lucien C.…[et al.]. 2012. Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-473262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rosales-Corral, Sergio A.…[et al.]. Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-473262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rosales-Corral, Sergio A.& López-Armas, Gabriela& Cruz-Ramos, J. A.& Melnikov, Valery G.& Tan, Dun Xian& Manchester, Lucien C.…[et al.]. Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-473262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر