Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin
Joint Authors
Melnikov, Valery G.
Manchester, Lucien C.
López-Armas, Gabriela
Tan, Dun Xian
Rosales-Corral, Sergio A.
Cruz-Ramos, J. A.
Reiter, Russel J.
Munoz, Ruben
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Alzheimer pathogenesis involves mitochondrial dysfunction, which is closely related to amyloid-β (Aβ) generation, abnormal tau phosphorylation, oxidative stress, and apoptosis.
Alterations in membranal components, including cholesterol and fatty acids, their characteristics, disposition, and distribution along the membranes, have been studied as evidence of cell membrane alterations in AD brain.
The majority of these studies have been focused on the cytoplasmic membrane; meanwhile the mitochondrial membranes have been less explored.
In this work, we studied lipids and mitochondrial membranes in vivo, following intracerebral injection of fibrillar amyloid-β (Aβ).
The purpose was to determine how Aβ may be responsible for beginning of a vicious cycle where oxidative stress and alterations in cholesterol, lipids and fatty acids, feed back on each other to cause mitochondrial dysfunction.
We observed changes in mitochondrial membrane lipids, and fatty acids, following intracerebral injection of fibrillar Aβ in aged Wistar rats.
Melatonin, a well-known antioxidant and neuroimmunomodulator indoleamine, reversed some of these alterations and protected mitochondrial membranes from obvious damage.
Additionally, melatonin increased the levels of linolenic and n-3 eicosapentaenoic acid, in the same site where amyloid β was injected, favoring an endogenous anti-inflammatory pathway.
American Psychological Association (APA)
Rosales-Corral, Sergio A.& López-Armas, Gabriela& Cruz-Ramos, J. A.& Melnikov, Valery G.& Tan, Dun Xian& Manchester, Lucien C.…[et al.]. 2012. Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-473262
Modern Language Association (MLA)
Rosales-Corral, Sergio A.…[et al.]. Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-473262
American Medical Association (AMA)
Rosales-Corral, Sergio A.& López-Armas, Gabriela& Cruz-Ramos, J. A.& Melnikov, Valery G.& Tan, Dun Xian& Manchester, Lucien C.…[et al.]. Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β : A Protective Role of Melatonin. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-473262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473262