Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility
المؤلفون المشاركون
Purohit, Nupur
Gupta, Sarita
Pillai, Prakash
Belani, Muskaan
Gupta, Sharad
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Changes in lifestyle lead to insulin resistance (IR) in females ultimately predisposing them towards infertility.
In addition, cadmium (Cd), an environmental endocrine disruptor, is reported for detrimental effects on granulosa cells, thus leading to ovarian dysfunction.
A combination of these factors, lifestyle and environment, seems to play a role in etiology of idiopathic infertility that accounts for 50% amongst the total infertility cases.
To address this issue, we made an attempt to investigate the extent of Cd impact on insulin-resistant (IR) granulosa cells.
We exposed adult female Charles Foster rats to dexamethasone and confirmed IR condition by fasting insulin resistance index (FIRI).
On treatment of IR rats with Cd, the preliminary studies demonstrated prolonged estrous cyclicity, decrease in serum estradiol concentrations, abnormal histology of ovary, and increased granulosa cell death.
Further gene and protein expression studies of steroidogenic acute regulatory (StAR) protein, 17β-hydroxysteroid dehydrogenase (17β-HSD), and cytochrome P450 aromatase (CYP19A1) were performed.
Protein expression studies demonstrated significant decrease in treated groups when compared with control.
Study revealed that, in spite of the molecular parameters being affected at varied level, overall ovarian physiology is maximally affected in IR and Cd coexposed group, thus mimicking the condition similar to those prevailing in infertile females.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Belani, Muskaan& Purohit, Nupur& Pillai, Prakash& Gupta, Sharad& Gupta, Sarita. 2014. Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Belani, Muskaan…[et al.]. Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-473284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Belani, Muskaan& Purohit, Nupur& Pillai, Prakash& Gupta, Sharad& Gupta, Sarita. Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر