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Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility
Joint Authors
Purohit, Nupur
Gupta, Sarita
Pillai, Prakash
Belani, Muskaan
Gupta, Sharad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Changes in lifestyle lead to insulin resistance (IR) in females ultimately predisposing them towards infertility.
In addition, cadmium (Cd), an environmental endocrine disruptor, is reported for detrimental effects on granulosa cells, thus leading to ovarian dysfunction.
A combination of these factors, lifestyle and environment, seems to play a role in etiology of idiopathic infertility that accounts for 50% amongst the total infertility cases.
To address this issue, we made an attempt to investigate the extent of Cd impact on insulin-resistant (IR) granulosa cells.
We exposed adult female Charles Foster rats to dexamethasone and confirmed IR condition by fasting insulin resistance index (FIRI).
On treatment of IR rats with Cd, the preliminary studies demonstrated prolonged estrous cyclicity, decrease in serum estradiol concentrations, abnormal histology of ovary, and increased granulosa cell death.
Further gene and protein expression studies of steroidogenic acute regulatory (StAR) protein, 17β-hydroxysteroid dehydrogenase (17β-HSD), and cytochrome P450 aromatase (CYP19A1) were performed.
Protein expression studies demonstrated significant decrease in treated groups when compared with control.
Study revealed that, in spite of the molecular parameters being affected at varied level, overall ovarian physiology is maximally affected in IR and Cd coexposed group, thus mimicking the condition similar to those prevailing in infertile females.
American Psychological Association (APA)
Belani, Muskaan& Purohit, Nupur& Pillai, Prakash& Gupta, Sharad& Gupta, Sarita. 2014. Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473284
Modern Language Association (MLA)
Belani, Muskaan…[et al.]. Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-473284
American Medical Association (AMA)
Belani, Muskaan& Purohit, Nupur& Pillai, Prakash& Gupta, Sharad& Gupta, Sarita. Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance : An Impact on Female Fertility. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473284