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Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors
المؤلفون المشاركون
Xu, Weidong
Wu, Yuanjian
Xu, Hongxing
Zhong, Qiao
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Human metapneumovirus (HMPV) is an important agent of acute respiratory tract infection in children, while its pathogenicity and molecular evolution are lacking.
Herein, we firstly report the synonymous codon usage patterns of HMPV genome.
The relative synonymous codon usage (RSCU) values, effective number of codon (ENC) values, nucleotide contents, and correlation analysis were performed among 17 available whole genome of HMPV, including different genotypes.
All preferred codons in HMPV are ended with A/U nucleotide and exhibited a great association with its high proportion of these two nucleotides in their genomes.
Mutation pressure rather than natural selection is the main influence factor that determines the bias of synonymous codon usage in HMPV.
The complementary pattern of codon usage bias between HMPV and human cell was observed, and this phenomenon suggests that host cells might be also act as an important factor to affect the codon usage bias.
Moreover, the codon usage biases in each HMPV genotypes are separated into different clades, which suggest that phylogenetic distance might involve in codon usage bias formation as well.
These analyses of synonymous codon usage bias in HMPV provide more information for better understanding its evolution and pathogenicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Qiao& Xu, Weidong& Wu, Yuanjian& Xu, Hongxing. 2012. Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Qiao…[et al.]. Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-473339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Qiao& Xu, Weidong& Wu, Yuanjian& Xu, Hongxing. Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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