Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors
Joint Authors
Xu, Weidong
Wu, Yuanjian
Xu, Hongxing
Zhong, Qiao
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Human metapneumovirus (HMPV) is an important agent of acute respiratory tract infection in children, while its pathogenicity and molecular evolution are lacking.
Herein, we firstly report the synonymous codon usage patterns of HMPV genome.
The relative synonymous codon usage (RSCU) values, effective number of codon (ENC) values, nucleotide contents, and correlation analysis were performed among 17 available whole genome of HMPV, including different genotypes.
All preferred codons in HMPV are ended with A/U nucleotide and exhibited a great association with its high proportion of these two nucleotides in their genomes.
Mutation pressure rather than natural selection is the main influence factor that determines the bias of synonymous codon usage in HMPV.
The complementary pattern of codon usage bias between HMPV and human cell was observed, and this phenomenon suggests that host cells might be also act as an important factor to affect the codon usage bias.
Moreover, the codon usage biases in each HMPV genotypes are separated into different clades, which suggest that phylogenetic distance might involve in codon usage bias formation as well.
These analyses of synonymous codon usage bias in HMPV provide more information for better understanding its evolution and pathogenicity.
American Psychological Association (APA)
Zhong, Qiao& Xu, Weidong& Wu, Yuanjian& Xu, Hongxing. 2012. Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473339
Modern Language Association (MLA)
Zhong, Qiao…[et al.]. Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-473339
American Medical Association (AMA)
Zhong, Qiao& Xu, Weidong& Wu, Yuanjian& Xu, Hongxing. Patterns of Synonymous Codon Usage on Human Metapneumovirus and Its Influencing Factors. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473339