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The Synthetic Compound Norcantharidin Induced Apoptosis in Mantle Cell Lymphoma In Vivo and In Vitro through the PI3K-Akt-NF-κB Signaling Pathway
المؤلفون المشاركون
Li, Yan
Fang, Jie
Lv, Hongyan
Song, Xiaoning
Zhang, Jinqiao
Du, Hengfei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study aimed to elucidate the antitumor activity of norcantharidin (NCTD) against human mantle cell lymphoma (MCL).
Cell proliferation and apoptosis were examined by MTS and flow cytometry.
Caspase-3, -8, and -9 activities were detected with a colorimetric caspase protease assay.
Apoptotic proteins—including PARP, cyclin D1, Bcl-2 family proteins, XIAP, and cIAP I—were studied by western blot.
The phosphoinositide 3 kinase (PI3K) inhibitor LY294002 was used to investigate the involvement of the PI3K/Akt signaling pathway.
In vivo studies were performed using Z138 cell xenografts in nude mice.
NCTD inhibited proliferation and induced apoptosis of Z138 and Mino cells, both in vitro and in vivo.
PI3Kp110α and p-Akt expressions were downregulated by NCTD treatment.
NCTD downregulated NF-κB activity by preventing NF-κB phosphorylation and nuclear translocation.
This effect was correlated with the suppression of NF-κB-regulated gene products, such as cyclin D1, BAX, survivin, Bcl-2, XIAP, and cIAP.
This phenomenon was blocked by the PI3K inhibitor LY294002.
Our results demonstrated that NCTD can induce growth arrest and apoptosis in MCL cells and that the mechanism may involve the PI3K/Akt/NF-κB signaling pathway.
NCTD may have therapeutic and/or adjuvant therapeutic applications in the treatment of MCL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Hongyan& Li, Yan& Du, Hengfei& Fang, Jie& Song, Xiaoning& Zhang, Jinqiao. 2013. The Synthetic Compound Norcantharidin Induced Apoptosis in Mantle Cell Lymphoma In Vivo and In Vitro through the PI3K-Akt-NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-473399
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Hongyan…[et al.]. The Synthetic Compound Norcantharidin Induced Apoptosis in Mantle Cell Lymphoma In Vivo and In Vitro through the PI3K-Akt-NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-473399
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Hongyan& Li, Yan& Du, Hengfei& Fang, Jie& Song, Xiaoning& Zhang, Jinqiao. The Synthetic Compound Norcantharidin Induced Apoptosis in Mantle Cell Lymphoma In Vivo and In Vitro through the PI3K-Akt-NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-473399
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473399
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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