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Hypoxia-Pretreated Human MSCs Attenuate Acute Kidney Injury through Enhanced Angiogenic and Antioxidative Capacities
المؤلفون المشاركون
Huo, Yanhong
Liu, Lirui
Zhang, Wenbo
Wang, Yaping
Yang, Yonghong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hypoxia preconditioning has been confirmed as an effective strategy to enhance the therapeutic potentials of mesenchymal stem cells (MSCs), such as for myocardial ischemia.
However, whether hypoxia preconditioning would produce beneficial effects on MSC-based renal repair has not been demonstrated.
In the study, we aimed to determine the feasibility and efficacy of hypoxia preconditioning to enhance MSC-based therapy of acute kidney injury (AKI).
MSCs were isolated from human adipose tissues.
The paracrine effects of MSCs under normoxia and hypoxia were determined in vitro.
Rats of AKI were induced by kidney I/R surgery and randomly divided into three groups: I/R control receiving PBS injection; MSC group receiving normal MSC injection; hypoMSC group receiving hypoxia-preconditioned MSC injection.
It was demonstrated in vitro that paracrine effects of MSCs were significantly enhanced, especially angiogenic factors.
Dihydroethidium (DHE) staining showed that antioxidative activities of MSCs were significantly enhanced by hypoxia stimulation.
Vascularization, apoptosis, and histological injury were all significantly improved in hypoMSC injected group compared with that in control and MSC injected groups.
Finally, the renal function was also significantly improved in hypoMSC injected group compared with that in the other two groups as assessed by the serum creatinine and BUN levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wenbo& Liu, Lirui& Huo, Yanhong& Yang, Yonghong& Wang, Yaping. 2014. Hypoxia-Pretreated Human MSCs Attenuate Acute Kidney Injury through Enhanced Angiogenic and Antioxidative Capacities. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473476
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wenbo…[et al.]. Hypoxia-Pretreated Human MSCs Attenuate Acute Kidney Injury through Enhanced Angiogenic and Antioxidative Capacities. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-473476
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wenbo& Liu, Lirui& Huo, Yanhong& Yang, Yonghong& Wang, Yaping. Hypoxia-Pretreated Human MSCs Attenuate Acute Kidney Injury through Enhanced Angiogenic and Antioxidative Capacities. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473476
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473476
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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