Both ERKMAPK and TGF-BetaSmad Signaling Pathways Play a Role in the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation
المؤلفون المشاركون
Peng, Xu
Cheng, Xiaoyun
Li, Yujuan
Liu, Xia
Gao, Wenke
Dang, Yongyan
Ye, Xiyun
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The notion that diabetic nephropathy is the leading cause of renal fibrosis prompted us to investigate the effects of blood glucose fluctuation (BGF) under high glucose condition on kidney in the mice.
Methods.
The diabetic and BGF animal models were established in this study.
Immunohistochemistry, Western blot, and RT-PCR analysis were applied to detect the expression of type I collagen, matrix metalloproteinase-1 (MMP1), metalloproteinase inhibitor 1 (TIMP1), transforming growth factor beta 1 (TGF-β1), phosphorylated-ERK, p38, smad2/3, and Akt.
Results.
BGF treatment increased type I collagen synthesis by two times compared with the control.
The expression of MMP1 was reduced markedly while TIMP1 synthesis was enhanced after BGF treatment.
ERK phosphorylation exhibits a significant increase in the mice treated with BGF.
Furthermore, BGF can markedly upregulate TGF-β1 expression.
The p-smad2 showed 2-fold increases compared with the only diabetic mice.
However, p-AKT levels were unchanged after BGF treatment.
Conclusions.
These data demonstrate that BGF can accelerate the trend of kidney fibrosis in diabetic mice by increasing collagen production and inhibiting collagen degradation.
Both ERK/MAPK and TGF-β/smad signaling pathways seem to play a role in the development of kidney fibrosis accelerated by blood glucose fluctuation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Xiaoyun& Gao, Wenke& Dang, Yongyan& Liu, Xia& Li, Yujuan& Peng, Xu…[et al.]. 2013. Both ERKMAPK and TGF-BetaSmad Signaling Pathways Play a Role in the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473599
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Xiaoyun…[et al.]. Both ERKMAPK and TGF-BetaSmad Signaling Pathways Play a Role in the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-473599
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Xiaoyun& Gao, Wenke& Dang, Yongyan& Liu, Xia& Li, Yujuan& Peng, Xu…[et al.]. Both ERKMAPK and TGF-BetaSmad Signaling Pathways Play a Role in the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473599
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473599
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر