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Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic
المؤلفون المشاركون
Miyamoto, Shinya
Shanker, Manish
Roth, Jack A.
Branch, Cynthia D.
Jin, Jiankang
Grimm, Elizabeth A.
Ramesh, Rajagopal
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cancer is a major health problem in the world.
Advances made in cancer therapy have improved the survival of patients in certain types of cancer.
However, the overall five-year survival has not significantly improved in the majority of cancer types.
Major challenges encountered in having effective cancer therapy are development of drug resistance by the tumor cells, nonspecific cytotoxicity, and inability to affect metastatic tumors by the chemodrugs.
Overcoming these challenges requires development and testing of novel therapies.
One attractive cancer therapeutic approach is cancer gene therapy.
Several laboratories including the authors' laboratory have been investigating nonviral formulations for delivering therapeutic genes as a mode for effective cancer therapy.
In this paper the authors will summarize their experience in the development and testing of a cationic lipid-based nanocarrier formulation and the results from their preclinical studies leading to a Phase I clinical trial for nonsmall cell lung cancer.
Their nanocarrier formulation containing therapeutic genes such as tumor suppressor genes when administered intravenously effectively controls metastatic tumor growth.
Additional Phase I clinical trials based on the results of their nanocarrier formulation have been initiated or proposed for treatment of cancer of the breast, ovary, pancreas, and metastatic melanoma, and will be discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shanker, Manish& Jin, Jiankang& Branch, Cynthia D.& Miyamoto, Shinya& Grimm, Elizabeth A.& Roth, Jack A.…[et al.]. 2011. Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shanker, Manish…[et al.]. Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic. Journal of Drug Delivery No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-473759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shanker, Manish& Jin, Jiankang& Branch, Cynthia D.& Miyamoto, Shinya& Grimm, Elizabeth A.& Roth, Jack A.…[et al.]. Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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