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Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives
المؤلفون المشاركون
Monteiro, Larissa
Lima, Rute M. F.
Melo, Ailton
de Oliveira, Diêgo M.
de Cerqueira, Martins D.
El-Bachá, Ramon S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-24
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy.
This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration.
Several mechanisms involved in ROS generation in neurodegeneration have been proposed.
Recent articles about molecular pathways involved in ROS generation were reviewed.
The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective.
Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS.
Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration.
Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed.
Finally, clinical trials testing potential neuroprotective agents were critically reviewed.
Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Melo, Ailton& Monteiro, Larissa& Lima, Rute M. F.& de Oliveira, Diêgo M.& de Cerqueira, Martins D.& El-Bachá, Ramon S.. 2011. Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-473797
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Melo, Ailton…[et al.]. Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-473797
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Melo, Ailton& Monteiro, Larissa& Lima, Rute M. F.& de Oliveira, Diêgo M.& de Cerqueira, Martins D.& El-Bachá, Ramon S.. Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-473797
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473797
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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