Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives
Joint Authors
Monteiro, Larissa
Lima, Rute M. F.
Melo, Ailton
de Oliveira, Diêgo M.
de Cerqueira, Martins D.
El-Bachá, Ramon S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy.
This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration.
Several mechanisms involved in ROS generation in neurodegeneration have been proposed.
Recent articles about molecular pathways involved in ROS generation were reviewed.
The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective.
Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS.
Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration.
Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed.
Finally, clinical trials testing potential neuroprotective agents were critically reviewed.
Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.
American Psychological Association (APA)
Melo, Ailton& Monteiro, Larissa& Lima, Rute M. F.& de Oliveira, Diêgo M.& de Cerqueira, Martins D.& El-Bachá, Ramon S.. 2011. Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-473797
Modern Language Association (MLA)
Melo, Ailton…[et al.]. Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-473797
American Medical Association (AMA)
Melo, Ailton& Monteiro, Larissa& Lima, Rute M. F.& de Oliveira, Diêgo M.& de Cerqueira, Martins D.& El-Bachá, Ramon S.. Oxidative Stress in Neurodegenerative Diseases : Mechanisms and Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-473797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473797