Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1 : Potential Roles of MAPK
المؤلفون المشاركون
Zou, Li-yi
Lee, Yong-woo
Kim, Yong-ho
Wu, Tie
Li, Li
Du, Ji-kun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-09
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Decursin (D), purified from Angelica gigas Nakai, has been proven to exert neuroprotective property.
Previous study revealed that D reduced Aβ25‒35-induced cytotoxicity in PC12 cells.
Our study explored the underlying mechanisms by which D mediates its therapeutic effects in vitro.
Pretreatment of cells with D diminished intracellular generation of ROS in response to Aβ25‒35.
Western blot revealed that D significantly increased the expression and activity of HO-1, which was correlated with its protection against Aβ25‒35-induced injury.
Addition of ZnPP, an HO-1 competitive inhibitor, significantly attenuated its protective effect in Aβ25‒35-treated cells, indicating the vital role of HO-1 resistance to oxidative injury.
Moreover, D induced Nrf2 nuclear translocation, the upstream of HO-1 expression.
While investigating the signaling pathways responsible for HO-1 induction, D activated ERK and dephosphorylated p38 in PC12 cells.
Addition of U0126, a selective inhibitor of ERK, blocked D-induced Nrf2 activation and HO-1 induction and meanwhile reversed the protection of D against Aβ25‒35-induced cell death.
These findings suggest D augments cellular antioxidant defense capacity through both intrinsic free radical scavenging activity and activation of MAPK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction, thereby protecting the PC12 cells from Aβ25‒35-induced oxidative cytotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Li& Du, Ji-kun& Zou, Li-yi& Wu, Tie& Lee, Yong-woo& Kim, Yong-ho. 2013. Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1 : Potential Roles of MAPK. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-473803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Li…[et al.]. Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1 : Potential Roles of MAPK. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-473803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Li& Du, Ji-kun& Zou, Li-yi& Wu, Tie& Lee, Yong-woo& Kim, Yong-ho. Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1 : Potential Roles of MAPK. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-473803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473803
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر