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Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers
المؤلفون المشاركون
Gibson, Matt
Beachley, Vince
Mao, Hai-Quan
Bandinelli, Pierre Alain
Coburn, Jeannine
Elisseeff, Jennifer H.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-29
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Biomaterials derived from the decellularization of mature tissues retain biological and architectural features that profoundly influence cellular activity.
However, the clinical utility of such materials remains limited as the shape and physical properties are difficult to control.
In contrast, scaffolds based on synthetic polymers can be engineered to exhibit specific physical properties, yet often suffer from limited biological functionality.
This study characterizes composite materials that present decellularized extracellular matrix (DECM) particles in combination with synthetic nanofibers and examines the ability of these materials to influence stem cell differentiation.
Mechanical processing of decellularized tissues yielded particles with diameters ranging from 71 to 334 nm.
Nanofiber scaffolds containing up to 10% DECM particles (wt/wt) derived from six different tissues were engineered and evaluated to confirm DECM particle incorporation and to measure bioactivity.
Scaffolds containing bone, cartilage, and fat promoted osteogenesis at 1 and 3 weeks compared to controls.
In contrast, spleen and lung DECM significantly reduced osteogenic outcomes compared to controls.
These findings highlight the potential to incorporate appropriate source DECM nanoparticles within nanofiber composites to design a scaffold with bioactivity targeted to specific applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gibson, Matt& Beachley, Vince& Coburn, Jeannine& Bandinelli, Pierre Alain& Mao, Hai-Quan& Elisseeff, Jennifer H.. 2014. Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473948
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gibson, Matt…[et al.]. Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-473948
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gibson, Matt& Beachley, Vince& Coburn, Jeannine& Bandinelli, Pierre Alain& Mao, Hai-Quan& Elisseeff, Jennifer H.. Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473948
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473948
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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