Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers
Joint Authors
Gibson, Matt
Beachley, Vince
Mao, Hai-Quan
Bandinelli, Pierre Alain
Coburn, Jeannine
Elisseeff, Jennifer H.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Biomaterials derived from the decellularization of mature tissues retain biological and architectural features that profoundly influence cellular activity.
However, the clinical utility of such materials remains limited as the shape and physical properties are difficult to control.
In contrast, scaffolds based on synthetic polymers can be engineered to exhibit specific physical properties, yet often suffer from limited biological functionality.
This study characterizes composite materials that present decellularized extracellular matrix (DECM) particles in combination with synthetic nanofibers and examines the ability of these materials to influence stem cell differentiation.
Mechanical processing of decellularized tissues yielded particles with diameters ranging from 71 to 334 nm.
Nanofiber scaffolds containing up to 10% DECM particles (wt/wt) derived from six different tissues were engineered and evaluated to confirm DECM particle incorporation and to measure bioactivity.
Scaffolds containing bone, cartilage, and fat promoted osteogenesis at 1 and 3 weeks compared to controls.
In contrast, spleen and lung DECM significantly reduced osteogenic outcomes compared to controls.
These findings highlight the potential to incorporate appropriate source DECM nanoparticles within nanofiber composites to design a scaffold with bioactivity targeted to specific applications.
American Psychological Association (APA)
Gibson, Matt& Beachley, Vince& Coburn, Jeannine& Bandinelli, Pierre Alain& Mao, Hai-Quan& Elisseeff, Jennifer H.. 2014. Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473948
Modern Language Association (MLA)
Gibson, Matt…[et al.]. Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-473948
American Medical Association (AMA)
Gibson, Matt& Beachley, Vince& Coburn, Jeannine& Bandinelli, Pierre Alain& Mao, Hai-Quan& Elisseeff, Jennifer H.. Tissue Extracellular Matrix Nanoparticle Presentation in Electrospun Nanofibers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-473948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473948