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Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways
المؤلفون المشاركون
Du, Guan-hua
Li, Yong-jie
Zhou, Si-bai
Zhang, Tian-tai
Song, Jun-ke
Li, Jin-ze
Liu, Rui
Sun, Jia-lin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Cerebrovascular accumulation of amyloid-β (Aβ) peptides in Alzheimer’s disease (AD) may contribute to disease progression through Aβ-induced microvascular endothelial pathogenesis.
Pinocembrin has been shown to have therapeutic effects in AD models.
These effects correlate with preservation of microvascular function, but the effect on endothelial cells under Aβ-damaged conditions is unclear.
The present study focuses on the in vitro protective effect of pinocembrin on fibrillar Aβ1−40 (fAβ1−40) injured human brain microvascular endothelial cells (hBMECs) and explores potential mechanisms.
The results demonstrate that fAβ1−40-induced cytotoxicity in hBMECs can be rescued by pinocembrin treatment.
Pinocembrin increases cell viability, reduces the release of LDH, and relieves nuclear condensation.
The mechanisms of this reversal from Aβ may be associated with the inhibition of inflammatory response, involving inhibition of MAPK activation, downregulation of phosphor-IKK level, relief of IκBα degradation, blockage of NF-κB p65 nuclear translocation, and reduction of the release of proinflammatory cytokines.
Pinocembrin does not show obvious effects on regulating the redox imbalance after exposure to fAβ1−40.
Together, the suppression of MAPK and the NF-κB signaling pathways play a significant role in the anti-inflammation of pinocembrin in hBMECs subjected to fAβ1−40.
This may serve as a therapeutic agent for BMEC protection in Alzheimer’s-related deficits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Rui& Li, Jin-ze& Song, Jun-ke& Sun, Jia-lin& Li, Yong-jie& Zhou, Si-bai…[et al.]. 2014. Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-474054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Rui…[et al.]. Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-474054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Rui& Li, Jin-ze& Song, Jun-ke& Sun, Jia-lin& Li, Yong-jie& Zhou, Si-bai…[et al.]. Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-474054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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