Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways
Joint Authors
Du, Guan-hua
Li, Yong-jie
Zhou, Si-bai
Zhang, Tian-tai
Song, Jun-ke
Li, Jin-ze
Liu, Rui
Sun, Jia-lin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cerebrovascular accumulation of amyloid-β (Aβ) peptides in Alzheimer’s disease (AD) may contribute to disease progression through Aβ-induced microvascular endothelial pathogenesis.
Pinocembrin has been shown to have therapeutic effects in AD models.
These effects correlate with preservation of microvascular function, but the effect on endothelial cells under Aβ-damaged conditions is unclear.
The present study focuses on the in vitro protective effect of pinocembrin on fibrillar Aβ1−40 (fAβ1−40) injured human brain microvascular endothelial cells (hBMECs) and explores potential mechanisms.
The results demonstrate that fAβ1−40-induced cytotoxicity in hBMECs can be rescued by pinocembrin treatment.
Pinocembrin increases cell viability, reduces the release of LDH, and relieves nuclear condensation.
The mechanisms of this reversal from Aβ may be associated with the inhibition of inflammatory response, involving inhibition of MAPK activation, downregulation of phosphor-IKK level, relief of IκBα degradation, blockage of NF-κB p65 nuclear translocation, and reduction of the release of proinflammatory cytokines.
Pinocembrin does not show obvious effects on regulating the redox imbalance after exposure to fAβ1−40.
Together, the suppression of MAPK and the NF-κB signaling pathways play a significant role in the anti-inflammation of pinocembrin in hBMECs subjected to fAβ1−40.
This may serve as a therapeutic agent for BMEC protection in Alzheimer’s-related deficits.
American Psychological Association (APA)
Liu, Rui& Li, Jin-ze& Song, Jun-ke& Sun, Jia-lin& Li, Yong-jie& Zhou, Si-bai…[et al.]. 2014. Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-474054
Modern Language Association (MLA)
Liu, Rui…[et al.]. Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-474054
American Medical Association (AMA)
Liu, Rui& Li, Jin-ze& Song, Jun-ke& Sun, Jia-lin& Li, Yong-jie& Zhou, Si-bai…[et al.]. Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPKNF- κ B Inflammatory Pathways. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-474054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474054