Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice
المؤلفون المشاركون
Naghshvar, Farshad
Jafarinejhad, Mehdi
Shokrzadeh, Mohammad
Chabra, Aroona
Mousavi, Seyed Abdollah
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The current study aimed to evaluate the protective effects of melatonin, a pineal secretory product, against hepatotoxicity induced by cyclophosphamide (CP) in mice.
Mice were pretreated with melatonin intraperitoneally for 7 consecutive days before the administration of a single intraperitoneal dose of 200 mg/kg CP.
24 hr after CP administration, the mice were anesthetized, blood was then removed, and serum toxicity enzymes activities were evaluated.
After the blood sampling, all animals were killed, livers were then removed, and histological studies were conducted.
Serum toxicity marker enzymes were significantly increased after CP treatment but restored in melatonin pretreated groups.
In addition, administration of CP induced necrotic hepatocyte with small crushed nuclei, portal space with severe inflammation, and hepatocytes surrounded by lymphocytic infiltration in hepatic tissues.
However, melatonin effectively protected against CP-induced histopathological abnormalities in the liver tissues.
Our results reveal that melatonin produces a potent hepatoprotective mechanism against CP.
Therefore, melatonin could be a potent candidate to use concomitantly as a supplement agent against hepatotoxicity of CP for the patients undergoing chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shokrzadeh, Mohammad& Mousavi, Seyed Abdollah& Naghshvar, Farshad& Chabra, Aroona& Jafarinejhad, Mehdi. 2014. Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474057
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shokrzadeh, Mohammad…[et al.]. Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-474057
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shokrzadeh, Mohammad& Mousavi, Seyed Abdollah& Naghshvar, Farshad& Chabra, Aroona& Jafarinejhad, Mehdi. Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474057
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474057
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر