Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice
Joint Authors
Naghshvar, Farshad
Jafarinejhad, Mehdi
Shokrzadeh, Mohammad
Chabra, Aroona
Mousavi, Seyed Abdollah
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The current study aimed to evaluate the protective effects of melatonin, a pineal secretory product, against hepatotoxicity induced by cyclophosphamide (CP) in mice.
Mice were pretreated with melatonin intraperitoneally for 7 consecutive days before the administration of a single intraperitoneal dose of 200 mg/kg CP.
24 hr after CP administration, the mice were anesthetized, blood was then removed, and serum toxicity enzymes activities were evaluated.
After the blood sampling, all animals were killed, livers were then removed, and histological studies were conducted.
Serum toxicity marker enzymes were significantly increased after CP treatment but restored in melatonin pretreated groups.
In addition, administration of CP induced necrotic hepatocyte with small crushed nuclei, portal space with severe inflammation, and hepatocytes surrounded by lymphocytic infiltration in hepatic tissues.
However, melatonin effectively protected against CP-induced histopathological abnormalities in the liver tissues.
Our results reveal that melatonin produces a potent hepatoprotective mechanism against CP.
Therefore, melatonin could be a potent candidate to use concomitantly as a supplement agent against hepatotoxicity of CP for the patients undergoing chemotherapy.
American Psychological Association (APA)
Shokrzadeh, Mohammad& Mousavi, Seyed Abdollah& Naghshvar, Farshad& Chabra, Aroona& Jafarinejhad, Mehdi. 2014. Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474057
Modern Language Association (MLA)
Shokrzadeh, Mohammad…[et al.]. Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-474057
American Medical Association (AMA)
Shokrzadeh, Mohammad& Mousavi, Seyed Abdollah& Naghshvar, Farshad& Chabra, Aroona& Jafarinejhad, Mehdi. Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474057