Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures

المؤلفون المشاركون

Pfeiffer, Erika
Hildebrand, Andreas A.
Damm, Georg
Metzler, Manfred

المصدر

International Journal of Spectroscopy

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-05-15

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الفيزياء

الملخص EN

Recent studies on the mammalian and fungal metabolism of the mycotoxin zearalenone (ZEN) have disclosed the formation of six regioisomers of monohydroxy-ZEN and its reductive metabolite zearalenol (ZEL).

Hydroxylation occurs at the aromatic ring or at one of four positions of the aliphatic macrocycle.

In addition, an aliphatic ZEN epoxide, its hydrolysis product, and other products were identified in fungal cultures.

In this paper, we report the product ion spectra of the [M-H]− ions of 22 oxidative metabolites of ZEN and ZEL, obtained by LC-MS2 analysis using a linear ion trap mass spectrometer with negative electrospray ionization.

The MS2 spectra exhibit qualitative and quantitative differences which allow a clear distinction of most metabolites.

Moreover, GC-MS analysis of the trimethylsilylated metabolites yields electron impact mass spectra with numerous fragment ions which can be used as fingerprint to confirm the chemical structure derived by LC-MS2 analysis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hildebrand, Andreas A.& Pfeiffer, Erika& Damm, Georg& Metzler, Manfred. 2012. Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures. International Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474201

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hildebrand, Andreas A.…[et al.]. Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures. International Journal of Spectroscopy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-474201

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hildebrand, Andreas A.& Pfeiffer, Erika& Damm, Georg& Metzler, Manfred. Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures. International Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474201

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-474201