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Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures
Joint Authors
Pfeiffer, Erika
Hildebrand, Andreas A.
Damm, Georg
Metzler, Manfred
Source
International Journal of Spectroscopy
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent studies on the mammalian and fungal metabolism of the mycotoxin zearalenone (ZEN) have disclosed the formation of six regioisomers of monohydroxy-ZEN and its reductive metabolite zearalenol (ZEL).
Hydroxylation occurs at the aromatic ring or at one of four positions of the aliphatic macrocycle.
In addition, an aliphatic ZEN epoxide, its hydrolysis product, and other products were identified in fungal cultures.
In this paper, we report the product ion spectra of the [M-H]− ions of 22 oxidative metabolites of ZEN and ZEL, obtained by LC-MS2 analysis using a linear ion trap mass spectrometer with negative electrospray ionization.
The MS2 spectra exhibit qualitative and quantitative differences which allow a clear distinction of most metabolites.
Moreover, GC-MS analysis of the trimethylsilylated metabolites yields electron impact mass spectra with numerous fragment ions which can be used as fingerprint to confirm the chemical structure derived by LC-MS2 analysis.
American Psychological Association (APA)
Hildebrand, Andreas A.& Pfeiffer, Erika& Damm, Georg& Metzler, Manfred. 2012. Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures. International Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474201
Modern Language Association (MLA)
Hildebrand, Andreas A.…[et al.]. Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures. International Journal of Spectroscopy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-474201
American Medical Association (AMA)
Hildebrand, Andreas A.& Pfeiffer, Erika& Damm, Georg& Metzler, Manfred. Combination of LC-MS2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures. International Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474201