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Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis
المؤلف
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Peritoneal dialysis (PD) is a therapeutic option for the treatment of end-stage renal disease and is based on the use of the peritoneum as a semipermeable membrane for the exchange of toxic solutes and water.
Long-term exposure of the peritoneal membrane to hyperosmotic PD fluids causes inflammation, loss of the mesothelial cells monolayer, fibrosis, vasculopathy, and angiogenesis, which may lead to peritoneal functional decline.
Peritonitis may further exacerbate the injury of the peritoneal membrane.
In parallel with these peritoneal alterations, mesothelial cells undergo an epithelial to mesenchymal transition (EMT), which has been associated with peritoneal deterioration.
Factors contributing to the bioincompatibility of classical PD fluids include the high content of glucose/glucose degradation products (GDPs) and their acidic pH.
New generation low-GDPs-neutral pH fluids have improved biocompatibility resulting in better preservation of the peritoneum.
However, standard glucose-based fluids are still needed, as biocompatible solutions are expensive for many potential users.
An alternative approach to preserve the peritoneal membrane, complementary to the efforts to improve fluid biocompatibility, is the use of pharmacological agents protecting the mesothelium.
This paper provides a comprehensive review of recent advances that point to the EMT of mesothelial cells as a potential therapeutic target to preserve membrane function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
López-Cabrera, Manuel. 2014. Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis. Advances in Medicine،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-474290
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
López-Cabrera, Manuel. Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis. Advances in Medicine No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-474290
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
López-Cabrera, Manuel. Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis. Advances in Medicine. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-474290
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474290
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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