Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Peritoneal dialysis (PD) is a therapeutic option for the treatment of end-stage renal disease and is based on the use of the peritoneum as a semipermeable membrane for the exchange of toxic solutes and water.
Long-term exposure of the peritoneal membrane to hyperosmotic PD fluids causes inflammation, loss of the mesothelial cells monolayer, fibrosis, vasculopathy, and angiogenesis, which may lead to peritoneal functional decline.
Peritonitis may further exacerbate the injury of the peritoneal membrane.
In parallel with these peritoneal alterations, mesothelial cells undergo an epithelial to mesenchymal transition (EMT), which has been associated with peritoneal deterioration.
Factors contributing to the bioincompatibility of classical PD fluids include the high content of glucose/glucose degradation products (GDPs) and their acidic pH.
New generation low-GDPs-neutral pH fluids have improved biocompatibility resulting in better preservation of the peritoneum.
However, standard glucose-based fluids are still needed, as biocompatible solutions are expensive for many potential users.
An alternative approach to preserve the peritoneal membrane, complementary to the efforts to improve fluid biocompatibility, is the use of pharmacological agents protecting the mesothelium.
This paper provides a comprehensive review of recent advances that point to the EMT of mesothelial cells as a potential therapeutic target to preserve membrane function.
American Psychological Association (APA)
López-Cabrera, Manuel. 2014. Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis. Advances in Medicine،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-474290
Modern Language Association (MLA)
López-Cabrera, Manuel. Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis. Advances in Medicine No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-474290
American Medical Association (AMA)
López-Cabrera, Manuel. Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis. Advances in Medicine. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-474290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474290