![](/images/graphics-bg.png)
Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats
المؤلفون المشاركون
Meng, Xue
Zheng, Xiaohui
Jia, Pu
Wang, Shixiang
Bian, Liujiao
Liao, Sha
Yu, Jie
Wu, Yizhen
Zhao, Xinfeng
Lan, Wei
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Bornyl gallate (BG) is a potential drug candidate synthesized by the reaction of two natural products, gallic acid and borneol.
Previous studies have strongly suggested that BG is worthy of further investigation due to antioxidant, antiatherosclerosis activities, and obvious activity of stimulating intersegmental vessel growth in zebrafish.
This work was designed to elucidate the metabolic profile of BG through analyzing its metabolites in vitro and in vivo by a chromatographic separation coupled with a mass spectrometry.
The metabolites of BG were characterized from the rat liver microsome incubation solution, as well as rat urine and plasma after oral administration.
Chromatographic separation was performed on an Agilent TC-C18 column (250 mm × 4.6 mm, 5 μm) with gradient elution using methanol and water containing 0.2% (V : V) formic acid as the mobile phase.
Metabolites identification involved analyzing the retention behaviors, changes of molecular weights and MS/MS fragment patterns of BG and the metabolites.
Five compounds were identified as isomers of hydroxylated BG metabolites in vitro.
The major metabolites of BG in rat urine and plasma proved to be BG-O-glucuronide and O-methyl BG-O-glucuronide.
The proposed method confirmed to be a reliable and sensitive alternative for characterizing metabolic pathways of BG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lan, Wei& Bian, Liujiao& Zhao, Xinfeng& Jia, Pu& Meng, Xue& Wu, Yizhen…[et al.]. 2013. Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats. Journal of Analytical Methods in Chemistry،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474355
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lan, Wei…[et al.]. Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats. Journal of Analytical Methods in Chemistry No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-474355
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lan, Wei& Bian, Liujiao& Zhao, Xinfeng& Jia, Pu& Meng, Xue& Wu, Yizhen…[et al.]. Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats. Journal of Analytical Methods in Chemistry. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474355
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474355
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)