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Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis
المؤلفون المشاركون
Choudhary, Manjusha
Singh, Surender
Gupta, Pankaj
Kumar, Vipin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Aim.
The present investigation was designed to evaluate antiarthritic potential of fractions of hydroalcoholic extract from leaves of P.
alba.
Materials and Methods.
Plumeria alba L.
leaves were extracted with hydroalcohol (30 : 70) to obtain hydroalcoholic extract of P.
alba.
This extract was further fractionated with solvents ethyl acetate and n-butanol to obtain EAPA and BPA, respectively.
These fractions were tested against formaldehyde and Freund’s complete adjuvant (FCA) induced arthritis.
Arthritis assessment, paw volume, body weight, motor incoordination, and nociceptive threshold were measured.
On day 21, the animals were sacrificed and histopathology was done.
Results.
The 100 and 200 mg/kg doses of EAPA and BPA caused a significant (P≤0.05–0.01) reduction in paw swelling in both models.
Erythrocyte sedimentation rate (ESR) and spleen weight decreased significantly (P<0.01) in arthritic rats treated with extracts.
There was significant (P<0.05) improvement in thymus weight in EAPA treated rats whereas significant (P<0.01) improvement was also seen in haemoglobin level (Hb) in diclofenac treated group.
Motor incoordination and nociceptive threshold were also significantly (P≤0.05–0.01) improved.
Conclusion.
The present study suggests that Plumeria alba L.
has protective activity against arthritis and supports the traditional use of P.
alba for rheumatism and other inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choudhary, Manjusha& Kumar, Vipin& Gupta, Pankaj& Singh, Surender. 2014. Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-474442
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choudhary, Manjusha…[et al.]. Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-474442
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choudhary, Manjusha& Kumar, Vipin& Gupta, Pankaj& Singh, Surender. Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-474442
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474442
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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