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Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis
Joint Authors
Choudhary, Manjusha
Singh, Surender
Gupta, Pankaj
Kumar, Vipin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aim.
The present investigation was designed to evaluate antiarthritic potential of fractions of hydroalcoholic extract from leaves of P.
alba.
Materials and Methods.
Plumeria alba L.
leaves were extracted with hydroalcohol (30 : 70) to obtain hydroalcoholic extract of P.
alba.
This extract was further fractionated with solvents ethyl acetate and n-butanol to obtain EAPA and BPA, respectively.
These fractions were tested against formaldehyde and Freund’s complete adjuvant (FCA) induced arthritis.
Arthritis assessment, paw volume, body weight, motor incoordination, and nociceptive threshold were measured.
On day 21, the animals were sacrificed and histopathology was done.
Results.
The 100 and 200 mg/kg doses of EAPA and BPA caused a significant (P≤0.05–0.01) reduction in paw swelling in both models.
Erythrocyte sedimentation rate (ESR) and spleen weight decreased significantly (P<0.01) in arthritic rats treated with extracts.
There was significant (P<0.05) improvement in thymus weight in EAPA treated rats whereas significant (P<0.01) improvement was also seen in haemoglobin level (Hb) in diclofenac treated group.
Motor incoordination and nociceptive threshold were also significantly (P≤0.05–0.01) improved.
Conclusion.
The present study suggests that Plumeria alba L.
has protective activity against arthritis and supports the traditional use of P.
alba for rheumatism and other inflammatory diseases.
American Psychological Association (APA)
Choudhary, Manjusha& Kumar, Vipin& Gupta, Pankaj& Singh, Surender. 2014. Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-474442
Modern Language Association (MLA)
Choudhary, Manjusha…[et al.]. Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-474442
American Medical Association (AMA)
Choudhary, Manjusha& Kumar, Vipin& Gupta, Pankaj& Singh, Surender. Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-474442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474442