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Sublethal Oxidative Stress Induces the Premature Senescence of Human Mesenchymal Stem Cells Derived from Endometrium
المؤلفون المشاركون
Borodkina, Aleksandra
Burova, Elena
Shatrova, Alla
Nikolsky, Nikolay
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
The specific responses of mesenchymal stem cells to oxidative stress may play a crucial role in regulation of tissue homeostasis as well as regeneration of organs after oxidative injury.
The responses of human endometrium-derived mesenchymal stem cells (hMESCs) to oxidative stress remain still unknown.
Herein, we examined the impact of H2O2 on cell viability, induction of premature senescence, and apoptosis.
hMESCs were highly resistant to H2O2 compared with human diploid fibroblasts.
To test a hypothesis whether hMESCs may undergo oxidative stress-induced premature senescence, cells were briefly exposed to the sublethal H2O2 doses.
H2O2-treated cells were permanently arrested, lost Ki67 proliferation marker, and exhibited a senescent phenotype including cell hypertrophy and increased SA-β-Gal activity.
Additionally, in stressed cells the expression levels of p21Cip1, SOD1, SOD2, and GPX1 were elevated.
hMESCs survived under stress were not able to resume proliferation, indicating the irreversible loss of proliferative potential.
While the low H2O2 doses promoted senescence in hMESCs, the higher H2O2 doses induced also apoptosis in a part of the cell population.
Of note, senescent hMESCs exhibited high resistance to apoptosis.
Thus, we have demonstrated for the first time that hMESCs may enter a state of premature senescence in response to sublethal oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burova, Elena& Borodkina, Aleksandra& Shatrova, Alla& Nikolsky, Nikolay. 2013. Sublethal Oxidative Stress Induces the Premature Senescence of Human Mesenchymal Stem Cells Derived from Endometrium. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-474474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burova, Elena…[et al.]. Sublethal Oxidative Stress Induces the Premature Senescence of Human Mesenchymal Stem Cells Derived from Endometrium. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-474474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burova, Elena& Borodkina, Aleksandra& Shatrova, Alla& Nikolsky, Nikolay. Sublethal Oxidative Stress Induces the Premature Senescence of Human Mesenchymal Stem Cells Derived from Endometrium. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-474474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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