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The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy
المؤلفون المشاركون
Kou, Jian-Qun
Ding, Xiao-Lan
Qin, Zheng-Hong
Zhu, Jia-Li
He, He
Wang, Shu-Zhi
Han, Rong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-25
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
This study investigated the effects of Naja naja atra venom (NNAV) on acute and chronic nephropathy in rats.
Rats received 6 mg/kg adriamycin (ADR) once to evoke the chronic nephropathy or 8 ml/kg 50% v/v glycerol to produce acute renal failure (ARF).
The NNAV was given orally once a day starting five days prior to ADR or glycerol injection and continued to the end of experiments.
The animals were placed in metabolic cages for 24 h for urine collection for urinary protein determination.
The kidney function-related biochemical changes and index of oxidative stress were determined with automatic biochemistry analyzer or colorimetric enzyme assay kits.
The pathomorphological changes were observed using light and transmission electron microcopies.
The levels of inflammatory cytokines and NF-κB activation were determined using ELISA kits, Western blot analysis, or immunofluorescence.
The results showed that NNAV relieved ADR-induced chronic nephropathy and glycerol-triggered acute renal failure syndromes including proteinuria, hypoalbuminemia, hyperlipidemia, serum electrolyte unbalance, renal oxidative stress, and pathological damages.
NNAV reduced kidney levels of TNF-α and IL-1β, but it increased the levels of IκB-α and inhibited NF-κB p65 nuclear localization.
These findings suggest that NNAV may be a valuable therapeutic drug for acute and chronic kidney diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Shu-Zhi& He, He& Han, Rong& Zhu, Jia-Li& Kou, Jian-Qun& Ding, Xiao-Lan…[et al.]. 2013. The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-474683
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Shu-Zhi…[et al.]. The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-474683
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Shu-Zhi& He, He& Han, Rong& Zhu, Jia-Li& Kou, Jian-Qun& Ding, Xiao-Lan…[et al.]. The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-474683
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474683
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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