The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy
Joint Authors
Kou, Jian-Qun
Ding, Xiao-Lan
Qin, Zheng-Hong
Zhu, Jia-Li
He, He
Wang, Shu-Zhi
Han, Rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This study investigated the effects of Naja naja atra venom (NNAV) on acute and chronic nephropathy in rats.
Rats received 6 mg/kg adriamycin (ADR) once to evoke the chronic nephropathy or 8 ml/kg 50% v/v glycerol to produce acute renal failure (ARF).
The NNAV was given orally once a day starting five days prior to ADR or glycerol injection and continued to the end of experiments.
The animals were placed in metabolic cages for 24 h for urine collection for urinary protein determination.
The kidney function-related biochemical changes and index of oxidative stress were determined with automatic biochemistry analyzer or colorimetric enzyme assay kits.
The pathomorphological changes were observed using light and transmission electron microcopies.
The levels of inflammatory cytokines and NF-κB activation were determined using ELISA kits, Western blot analysis, or immunofluorescence.
The results showed that NNAV relieved ADR-induced chronic nephropathy and glycerol-triggered acute renal failure syndromes including proteinuria, hypoalbuminemia, hyperlipidemia, serum electrolyte unbalance, renal oxidative stress, and pathological damages.
NNAV reduced kidney levels of TNF-α and IL-1β, but it increased the levels of IκB-α and inhibited NF-κB p65 nuclear localization.
These findings suggest that NNAV may be a valuable therapeutic drug for acute and chronic kidney diseases.
American Psychological Association (APA)
Wang, Shu-Zhi& He, He& Han, Rong& Zhu, Jia-Li& Kou, Jian-Qun& Ding, Xiao-Lan…[et al.]. 2013. The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-474683
Modern Language Association (MLA)
Wang, Shu-Zhi…[et al.]. The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-474683
American Medical Association (AMA)
Wang, Shu-Zhi& He, He& Han, Rong& Zhu, Jia-Li& Kou, Jian-Qun& Ding, Xiao-Lan…[et al.]. The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-474683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474683