Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV : Implications in Diabetes Management
المؤلفون المشاركون
Fan, Junfeng
Yousef, Gad
Johnson, Michelle H.
de Mejia, Elvira Gonzalez
Lila, Mary Ann
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-29
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Beneficial health effects of fruits and vegetables in the diet have been attributed to their high flavonoid content.
Dipeptidyl peptidase IV (DPP-IV) is a serine aminopeptidase that is a novel target for type 2 diabetes therapy due to its incretin hormone regulatory effects.
In this study, well-characterized anthocyanins (ANC) isolated from berry wine blends and twenty-seven other phenolic compounds commonly present in citrus, berry, grape, and soybean, were individually investigated for their inhibitory effects on DPP-IV by using a luminescence assay and computational modeling.
ANC from blueberry-blackberry wine blends strongly inhibited DPP-IV activity (IC50, 0.07 ± 0.02 to >300 μM).
Of the twenty-seven phenolics tested, the most potent DPP-IV inhibitors were resveratrol (IC50, 0.6 ± 0.4 nM), luteolin (0.12 ± 0.01 μM), apigenin (0.14 ± 0.02 μM), and flavone (0.17 ± 0.01 μM), with IC50 values lower than diprotin A (4.21 ± 2.01 μM), a reference standard inhibitory compound.
Analyses of computational modeling showed that resveratrol and flavone were competitive inhibitors which could dock directly into all three active sites of DPP-IV, while luteolin and apigenin docked in a noncompetitive manner.
Hydrogen bonding was the main binding mode of all tested phenolic compounds with DPP-IV.
These results indicate that flavonoids, particularly luteolin, apigenin, and flavone, and the stilbenoid resveratrol can act as naturally occurring DPP-IV inhibitors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Junfeng& Johnson, Michelle H.& Lila, Mary Ann& Yousef, Gad& de Mejia, Elvira Gonzalez. 2013. Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV : Implications in Diabetes Management. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-474822
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Junfeng…[et al.]. Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV : Implications in Diabetes Management. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-474822
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Junfeng& Johnson, Michelle H.& Lila, Mary Ann& Yousef, Gad& de Mejia, Elvira Gonzalez. Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV : Implications in Diabetes Management. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-474822
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474822
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر