QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats
المؤلفون المشاركون
Yang, Xiao-Yuan
Han, Jing-Yan
Wei, Xiao-Hong
Chen, Yuan-Yuan
Zhao, Hai-Ping
Tang, Dong-Xin
Liu, Yu-Ying
Li, Ping-Ping
Pan, Chun-Shui
Wang, Chuan-She
Fan, Jing-Yu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
QiShenYiQi Pills (QSYQ) is a compound Chinese medicine used for treatment of cardiovascular diseases.
The present study investigated the effects of QSYQ on the Doxorubicin- (DOX-) induced disorders in rat cardiac structure and function and the possible mechanism underlying.
A total of 24 male Sprague-Dawley rats were administrated by intraperitoneal injections with DOX at a dose of 2.5 mg/kg, once every day for a total of 6 times.
After the 6th injection, the rats were evaluated by echocardiographic analysis, and the animals with injured heart (n=14) were divided into 2 groups and further treated with (n=7) or without (n=7) QSYQ by gavage at a dose of 0.2 g/day, once a day, over the next 2 weeks.
Two weeks after QSYQ treatment, the following variables were assessed: myocardial blood flow (MBF) by Laser-Doppler Perfusion Imager, the ratio of heart weight to body weight (HW/BW), myocardial histology, myocardial content of ATP, AMP, free fatty acids (FFAs) and AMP/ATP by ELISA, and expression of PPARα, PGC-1α, and ATP 5D by Western blot.
Statistical analysis was performed using one-way ANOVA followed by Turkey test for multiple comparisons.
DOX challenge significantly increased left ventricular internal diameter and HW/BW and decreased the thickness of the left ventricular posterior wall, the left ventricle ejection fraction, and the left ventricle fractional shortening.
DOX also increased AMP, FFA, and AMP/ATP, decreased ATP, and downregulated the protein content of ATP 5D, PPAR α, and PGC-1 α.
All these DOX-induced cardiac insults were attenuated significantly by QSYQ treatment.
These results show the potential of QSYQ to ameliorate DOX-induced disorders in cardiac structure and function; this effect may be related to the increase in myocardial ATP content via the upregulation of ATP 5D, PPAR α, and PGC-1 α and the oxidation of FFA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Dong-Xin& Zhao, Hai-Ping& Pan, Chun-Shui& Liu, Yu-Ying& Wei, Xiao-Hong& Yang, Xiao-Yuan…[et al.]. 2013. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Dong-Xin…[et al.]. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-474909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Dong-Xin& Zhao, Hai-Ping& Pan, Chun-Shui& Liu, Yu-Ying& Wei, Xiao-Hong& Yang, Xiao-Yuan…[et al.]. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر