![](/images/graphics-bg.png)
QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats
Joint Authors
Yang, Xiao-Yuan
Han, Jing-Yan
Wei, Xiao-Hong
Chen, Yuan-Yuan
Zhao, Hai-Ping
Tang, Dong-Xin
Liu, Yu-Ying
Li, Ping-Ping
Pan, Chun-Shui
Wang, Chuan-She
Fan, Jing-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
QiShenYiQi Pills (QSYQ) is a compound Chinese medicine used for treatment of cardiovascular diseases.
The present study investigated the effects of QSYQ on the Doxorubicin- (DOX-) induced disorders in rat cardiac structure and function and the possible mechanism underlying.
A total of 24 male Sprague-Dawley rats were administrated by intraperitoneal injections with DOX at a dose of 2.5 mg/kg, once every day for a total of 6 times.
After the 6th injection, the rats were evaluated by echocardiographic analysis, and the animals with injured heart (n=14) were divided into 2 groups and further treated with (n=7) or without (n=7) QSYQ by gavage at a dose of 0.2 g/day, once a day, over the next 2 weeks.
Two weeks after QSYQ treatment, the following variables were assessed: myocardial blood flow (MBF) by Laser-Doppler Perfusion Imager, the ratio of heart weight to body weight (HW/BW), myocardial histology, myocardial content of ATP, AMP, free fatty acids (FFAs) and AMP/ATP by ELISA, and expression of PPARα, PGC-1α, and ATP 5D by Western blot.
Statistical analysis was performed using one-way ANOVA followed by Turkey test for multiple comparisons.
DOX challenge significantly increased left ventricular internal diameter and HW/BW and decreased the thickness of the left ventricular posterior wall, the left ventricle ejection fraction, and the left ventricle fractional shortening.
DOX also increased AMP, FFA, and AMP/ATP, decreased ATP, and downregulated the protein content of ATP 5D, PPAR α, and PGC-1 α.
All these DOX-induced cardiac insults were attenuated significantly by QSYQ treatment.
These results show the potential of QSYQ to ameliorate DOX-induced disorders in cardiac structure and function; this effect may be related to the increase in myocardial ATP content via the upregulation of ATP 5D, PPAR α, and PGC-1 α and the oxidation of FFA.
American Psychological Association (APA)
Tang, Dong-Xin& Zhao, Hai-Ping& Pan, Chun-Shui& Liu, Yu-Ying& Wei, Xiao-Hong& Yang, Xiao-Yuan…[et al.]. 2013. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474909
Modern Language Association (MLA)
Tang, Dong-Xin…[et al.]. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-474909
American Medical Association (AMA)
Tang, Dong-Xin& Zhao, Hai-Ping& Pan, Chun-Shui& Liu, Yu-Ying& Wei, Xiao-Hong& Yang, Xiao-Yuan…[et al.]. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474909