Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy
المؤلفون المشاركون
de Waure, Chiara
La Torre, Giuseppe
Nicolotti, Nicola
Clemente, Gennaro
Siliquini, Roberta
Ricciardi, Gualtiero
Gualano, Maria Rosaria
Sferrazza, Antonella
Nuzzo, Gennaro
Boccia, Antonio
De Rose, Agostino Maria
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The aims of the present research are to investigate the possible predictors of pancreatic cancer, in particular smoking status, alcohol consumption, hypercholesterolemia, and diabetes mellitus, in patients with histologically confirmed pancreatic carcinoma and to examine the synergism between risk factors.
A case-control study (80 patients and 392 controls) was conducted at the Teaching Hospital “Agostino Gemelli” in Rome.
A conditional logistic regression was used for the statistical analysis and results were presented as odds ratio (OR) and 95% confidence intervals (95% CI).
We also investigated the possible interactions between risk factors and calculated the synergism index (SI).
The multivariate analysis revealed that hypercholesterolemia and alcohol consumption resulted in important risk factors for pancreatic cancer even after the adjustment for all variables (OR: 5.05, 95% CI: 2.94–8.66; OR: 2.25, 95% CI: 1.30–3.89, resp.).
Interestingly, important synergistic interactions between risk factors were found, especially between ever smoking status and alcohol consumptions (SI = 17.61) as well as alcohol consumption and diabetes (SI = 17.77).
In conclusion, the study confirms that hypercholesterolemia and alcohol consumption represent significant and independent risk factors for pancreatic cancer.
Moreover, there is evidence of synergistic interaction between diabetes and lifestyle factors (drinking alcohol and eating fatty foods).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
La Torre, Giuseppe& Sferrazza, Antonella& Gualano, Maria Rosaria& de Waure, Chiara& Clemente, Gennaro& De Rose, Agostino Maria…[et al.]. 2014. Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474965
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
La Torre, Giuseppe…[et al.]. Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-474965
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
La Torre, Giuseppe& Sferrazza, Antonella& Gualano, Maria Rosaria& de Waure, Chiara& Clemente, Gennaro& De Rose, Agostino Maria…[et al.]. Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474965
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474965
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر