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Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy
Joint Authors
de Waure, Chiara
La Torre, Giuseppe
Nicolotti, Nicola
Clemente, Gennaro
Siliquini, Roberta
Ricciardi, Gualtiero
Gualano, Maria Rosaria
Sferrazza, Antonella
Nuzzo, Gennaro
Boccia, Antonio
De Rose, Agostino Maria
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aims of the present research are to investigate the possible predictors of pancreatic cancer, in particular smoking status, alcohol consumption, hypercholesterolemia, and diabetes mellitus, in patients with histologically confirmed pancreatic carcinoma and to examine the synergism between risk factors.
A case-control study (80 patients and 392 controls) was conducted at the Teaching Hospital “Agostino Gemelli” in Rome.
A conditional logistic regression was used for the statistical analysis and results were presented as odds ratio (OR) and 95% confidence intervals (95% CI).
We also investigated the possible interactions between risk factors and calculated the synergism index (SI).
The multivariate analysis revealed that hypercholesterolemia and alcohol consumption resulted in important risk factors for pancreatic cancer even after the adjustment for all variables (OR: 5.05, 95% CI: 2.94–8.66; OR: 2.25, 95% CI: 1.30–3.89, resp.).
Interestingly, important synergistic interactions between risk factors were found, especially between ever smoking status and alcohol consumptions (SI = 17.61) as well as alcohol consumption and diabetes (SI = 17.77).
In conclusion, the study confirms that hypercholesterolemia and alcohol consumption represent significant and independent risk factors for pancreatic cancer.
Moreover, there is evidence of synergistic interaction between diabetes and lifestyle factors (drinking alcohol and eating fatty foods).
American Psychological Association (APA)
La Torre, Giuseppe& Sferrazza, Antonella& Gualano, Maria Rosaria& de Waure, Chiara& Clemente, Gennaro& De Rose, Agostino Maria…[et al.]. 2014. Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474965
Modern Language Association (MLA)
La Torre, Giuseppe…[et al.]. Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-474965
American Medical Association (AMA)
La Torre, Giuseppe& Sferrazza, Antonella& Gualano, Maria Rosaria& de Waure, Chiara& Clemente, Gennaro& De Rose, Agostino Maria…[et al.]. Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer : A Case-Control Study in Italy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474965