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Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain
المؤلفون المشاركون
Carbone, Francesca
Lebovici, Andrei
Sfrangeu, Silviu A.
Fanea, Laura
David, Leontin I.
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Neurological disorders represent major causes of lost years of healthy life and mortality worldwide.
Development of their quantitative interdisciplinary in vivo evaluation is required.
Compartment modeling (CM) of brain data acquired in vivo using magnetic resonance imaging techniques with clinically available contrast agents can be performed to quantitatively assess brain perfusion.
Transport of 1H spins in water molecules across physiological compartmental brain barriers in three different pools was mathematically modeled and theoretically evaluated in this paper and the corresponding theoretical compartment modeling of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data was analyzed.
The pools considered were blood, tissue, and cerebrospinal fluid (CSF).
The blood and CSF data were mathematically modeled assuming continuous flow of the 1H spins in these pools.
Tissue data was modeled using three CMs.
Results in this paper show that transport across physiological brain barriers such as the blood to brain barrier, the extracellular space to the intracellular space barrier, or the blood to CSF barrier can be evaluated quantitatively.
Statistical evaluations of this quantitative information may be performed to assess tissue perfusion, barriers' integrity, and CSF flow in vivo in the normal or disease-affected brain or to assess response to therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fanea, Laura& David, Leontin I.& Lebovici, Andrei& Carbone, Francesca& Sfrangeu, Silviu A.. 2012. Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475111
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fanea, Laura…[et al.]. Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-475111
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fanea, Laura& David, Leontin I.& Lebovici, Andrei& Carbone, Francesca& Sfrangeu, Silviu A.. Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475111
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475111
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