Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain
Joint Authors
Carbone, Francesca
Lebovici, Andrei
Sfrangeu, Silviu A.
Fanea, Laura
David, Leontin I.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Neurological disorders represent major causes of lost years of healthy life and mortality worldwide.
Development of their quantitative interdisciplinary in vivo evaluation is required.
Compartment modeling (CM) of brain data acquired in vivo using magnetic resonance imaging techniques with clinically available contrast agents can be performed to quantitatively assess brain perfusion.
Transport of 1H spins in water molecules across physiological compartmental brain barriers in three different pools was mathematically modeled and theoretically evaluated in this paper and the corresponding theoretical compartment modeling of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data was analyzed.
The pools considered were blood, tissue, and cerebrospinal fluid (CSF).
The blood and CSF data were mathematically modeled assuming continuous flow of the 1H spins in these pools.
Tissue data was modeled using three CMs.
Results in this paper show that transport across physiological brain barriers such as the blood to brain barrier, the extracellular space to the intracellular space barrier, or the blood to CSF barrier can be evaluated quantitatively.
Statistical evaluations of this quantitative information may be performed to assess tissue perfusion, barriers' integrity, and CSF flow in vivo in the normal or disease-affected brain or to assess response to therapy.
American Psychological Association (APA)
Fanea, Laura& David, Leontin I.& Lebovici, Andrei& Carbone, Francesca& Sfrangeu, Silviu A.. 2012. Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475111
Modern Language Association (MLA)
Fanea, Laura…[et al.]. Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-475111
American Medical Association (AMA)
Fanea, Laura& David, Leontin I.& Lebovici, Andrei& Carbone, Francesca& Sfrangeu, Silviu A.. Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475111