Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Dhananjaya Naidu, M.
Madhavi, K.
Visweswara Rao, Pasupuleti
Gan, Siew Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The present study was conducted to evaluate the therapeutic efficacy of Rhinacanthus nasutus (R.
nasutus) on mitochondrial and cytosolic enzymes in streptozotocin-induced diabetic rats.
The rats were divided into five groups with 6 rats in each group.
The methanolic extract of R.
nasutus was orally administered at a dose of 200 mg/kg/day, and glibenclamide was administered at a dose of 50 mg/kg/day.
All animals were treated for 30 days and were sacrificed.
The activities of both intra- and extramitochondrial enzymes including glucose-6-phosphate dehydrogenase (G6PDH), succinate dehydrogenase (SDH), glutamate dehydrogenase (GDH), and lactate dehydrogenase (LDH) were measured in the livers of the animals.
The levels of G6PDH, SDH, and GDH were significantly reduced in the diabetic rats but were significantly increased after 30 days of R.
nasutus treatment.
The increased LDH level in diabetic rats exhibited a significant reduction after treatment with R.
nasutus.
These results indicate that the administration of R.
nasutus altered the activities of oxidative enzymes in a positive manner, indicating that R.
nasutus improves mitochondrial energy production.
Our data suggest that R.
nasutus should be further explored for its role in the treatment of diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Visweswara Rao, Pasupuleti& Madhavi, K.& Dhananjaya Naidu, M.& Gan, Siew Hua. 2013. Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-475436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Visweswara Rao, Pasupuleti…[et al.]. Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-475436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Visweswara Rao, Pasupuleti& Madhavi, K.& Dhananjaya Naidu, M.& Gan, Siew Hua. Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-475436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر