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Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats
Joint Authors
Dhananjaya Naidu, M.
Madhavi, K.
Visweswara Rao, Pasupuleti
Gan, Siew Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study was conducted to evaluate the therapeutic efficacy of Rhinacanthus nasutus (R.
nasutus) on mitochondrial and cytosolic enzymes in streptozotocin-induced diabetic rats.
The rats were divided into five groups with 6 rats in each group.
The methanolic extract of R.
nasutus was orally administered at a dose of 200 mg/kg/day, and glibenclamide was administered at a dose of 50 mg/kg/day.
All animals were treated for 30 days and were sacrificed.
The activities of both intra- and extramitochondrial enzymes including glucose-6-phosphate dehydrogenase (G6PDH), succinate dehydrogenase (SDH), glutamate dehydrogenase (GDH), and lactate dehydrogenase (LDH) were measured in the livers of the animals.
The levels of G6PDH, SDH, and GDH were significantly reduced in the diabetic rats but were significantly increased after 30 days of R.
nasutus treatment.
The increased LDH level in diabetic rats exhibited a significant reduction after treatment with R.
nasutus.
These results indicate that the administration of R.
nasutus altered the activities of oxidative enzymes in a positive manner, indicating that R.
nasutus improves mitochondrial energy production.
Our data suggest that R.
nasutus should be further explored for its role in the treatment of diabetes mellitus.
American Psychological Association (APA)
Visweswara Rao, Pasupuleti& Madhavi, K.& Dhananjaya Naidu, M.& Gan, Siew Hua. 2013. Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-475436
Modern Language Association (MLA)
Visweswara Rao, Pasupuleti…[et al.]. Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-475436
American Medical Association (AMA)
Visweswara Rao, Pasupuleti& Madhavi, K.& Dhananjaya Naidu, M.& Gan, Siew Hua. Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-475436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475436