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Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus
المؤلفون المشاركون
Chaukar, Devendra Arvind
Juvekar, Shashikant
Ghosh, Sarbani
Pai, P.
D'cruz, Anil
Patil, Vijay Maruti
Chatturvedi, Pankaj
Krishna, Muddu Vamshi
Murthy, Vedang
Joshi, Amit
Noronha, Vanita
Agarwal, Jai Prakash
Prabhash, Kumar
Dhumal, Sachin
المصدر
Chemotherapy Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Locally advanced carcinoma of maxillary sinus has been historically reported to have poor prognosis.
We evaluated the role of NACT in improving the outcome in these patients.
Methods.
41 patients with locally advanced technically unresectable (stage IVa) or unresectable maxillary carcinoma (stage IVb) were treated with induction chemotherapy between 2008 and 2011.
The demographic profile, response and toxicity of chemotherapy, definitive treatment received, progression free survival (PFS), and overall survival (OS) were analyzed.
Univariate and multivariate analysis were performed to determine factors associated with PFS and OS.
Results.
The chemotherapy included two drugs (platinum and taxane) in 34 patients (82.9%) and three drugs (platinum, taxane, and 5 FU) in 7 (17.1%).
There was no complete response seen in any of the patients, stable disease in 18 (43.9%), partial response in 16 (39%), and progression in 7 (17.1%) patients.
After induction, the treatment planned included surgery in 12 (29.3%), CT-RT in 24 (58.5%), radical RT in 1 (2.4%), palliative RT in 1 (2.4%), and palliative chemotherapy in 3 (7.3%) patients.
Overall, the median PFS was 10.0 months.
The OS at 24 months and 36 months was 41% and 35%, respectively.
Conclusion.
In unresectable maxillary carcinoma, induction chemotherapy has clinically significant benefit with acceptable toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Noronha, Vanita& Patil, Vijay Maruti& Joshi, Amit& Krishna, Muddu Vamshi& Dhumal, Sachin& Juvekar, Shashikant…[et al.]. 2014. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475624
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Noronha, Vanita…[et al.]. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-475624
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Noronha, Vanita& Patil, Vijay Maruti& Joshi, Amit& Krishna, Muddu Vamshi& Dhumal, Sachin& Juvekar, Shashikant…[et al.]. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475624
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475624
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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