Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus

Joint Authors

Chaukar, Devendra Arvind
Juvekar, Shashikant
Ghosh, Sarbani
Pai, P.
D'cruz, Anil
Patil, Vijay Maruti
Chatturvedi, Pankaj
Krishna, Muddu Vamshi
Murthy, Vedang
Joshi, Amit
Noronha, Vanita
Agarwal, Jai Prakash
Prabhash, Kumar
Dhumal, Sachin

Source

Chemotherapy Research and Practice

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-05-11

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Pharmacology

Abstract EN

Background.

Locally advanced carcinoma of maxillary sinus has been historically reported to have poor prognosis.

We evaluated the role of NACT in improving the outcome in these patients.

Methods.

41 patients with locally advanced technically unresectable (stage IVa) or unresectable maxillary carcinoma (stage IVb) were treated with induction chemotherapy between 2008 and 2011.

The demographic profile, response and toxicity of chemotherapy, definitive treatment received, progression free survival (PFS), and overall survival (OS) were analyzed.

Univariate and multivariate analysis were performed to determine factors associated with PFS and OS.

Results.

The chemotherapy included two drugs (platinum and taxane) in 34 patients (82.9%) and three drugs (platinum, taxane, and 5 FU) in 7 (17.1%).

There was no complete response seen in any of the patients, stable disease in 18 (43.9%), partial response in 16 (39%), and progression in 7 (17.1%) patients.

After induction, the treatment planned included surgery in 12 (29.3%), CT-RT in 24 (58.5%), radical RT in 1 (2.4%), palliative RT in 1 (2.4%), and palliative chemotherapy in 3 (7.3%) patients.

Overall, the median PFS was 10.0 months.

The OS at 24 months and 36 months was 41% and 35%, respectively.

Conclusion.

In unresectable maxillary carcinoma, induction chemotherapy has clinically significant benefit with acceptable toxicity.

American Psychological Association (APA)

Noronha, Vanita& Patil, Vijay Maruti& Joshi, Amit& Krishna, Muddu Vamshi& Dhumal, Sachin& Juvekar, Shashikant…[et al.]. 2014. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475624

Modern Language Association (MLA)

Noronha, Vanita…[et al.]. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-475624

American Medical Association (AMA)

Noronha, Vanita& Patil, Vijay Maruti& Joshi, Amit& Krishna, Muddu Vamshi& Dhumal, Sachin& Juvekar, Shashikant…[et al.]. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475624

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-475624