Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus
Joint Authors
Chaukar, Devendra Arvind
Juvekar, Shashikant
Ghosh, Sarbani
Pai, P.
D'cruz, Anil
Patil, Vijay Maruti
Chatturvedi, Pankaj
Krishna, Muddu Vamshi
Murthy, Vedang
Joshi, Amit
Noronha, Vanita
Agarwal, Jai Prakash
Prabhash, Kumar
Dhumal, Sachin
Source
Chemotherapy Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Locally advanced carcinoma of maxillary sinus has been historically reported to have poor prognosis.
We evaluated the role of NACT in improving the outcome in these patients.
Methods.
41 patients with locally advanced technically unresectable (stage IVa) or unresectable maxillary carcinoma (stage IVb) were treated with induction chemotherapy between 2008 and 2011.
The demographic profile, response and toxicity of chemotherapy, definitive treatment received, progression free survival (PFS), and overall survival (OS) were analyzed.
Univariate and multivariate analysis were performed to determine factors associated with PFS and OS.
Results.
The chemotherapy included two drugs (platinum and taxane) in 34 patients (82.9%) and three drugs (platinum, taxane, and 5 FU) in 7 (17.1%).
There was no complete response seen in any of the patients, stable disease in 18 (43.9%), partial response in 16 (39%), and progression in 7 (17.1%) patients.
After induction, the treatment planned included surgery in 12 (29.3%), CT-RT in 24 (58.5%), radical RT in 1 (2.4%), palliative RT in 1 (2.4%), and palliative chemotherapy in 3 (7.3%) patients.
Overall, the median PFS was 10.0 months.
The OS at 24 months and 36 months was 41% and 35%, respectively.
Conclusion.
In unresectable maxillary carcinoma, induction chemotherapy has clinically significant benefit with acceptable toxicity.
American Psychological Association (APA)
Noronha, Vanita& Patil, Vijay Maruti& Joshi, Amit& Krishna, Muddu Vamshi& Dhumal, Sachin& Juvekar, Shashikant…[et al.]. 2014. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475624
Modern Language Association (MLA)
Noronha, Vanita…[et al.]. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-475624
American Medical Association (AMA)
Noronha, Vanita& Patil, Vijay Maruti& Joshi, Amit& Krishna, Muddu Vamshi& Dhumal, Sachin& Juvekar, Shashikant…[et al.]. Induction Chemotherapy in Technically Unresectable Locally Advanced Carcinoma of Maxillary Sinus. Chemotherapy Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475624