Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis
المؤلفون المشاركون
Sultani, Masooma
Stringer, Andrea M.
Bowen, Joanne M.
Gibson, Rachel J.
المصدر
Chemotherapy Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
“Mucositis” is the clinical term used to describe ulceration and damage of the mucous membranes of the entire gastrointestinal tract (GIT) following cytotoxic cancer chemotherapy and radiation therapy common symptoms include abdominal pain, bloating, diarrhoea, vomiting, and constipation resulting in both a significant clinical and financial burden.
Chemotherapeutic drugs cause upregulation of stress response genes including NFκB, that in turn upregulate the production of proinflammatory cytokines such as interleukin-1β (IL-1β), Interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α).
These proinflammatory cytokines are responsible for initiating inflammation in response to tissue injury.
Anti-inflammatory cytokines and specific cytokine inhibitors are also released to limit the sustained or excessive inflammatory reactions.
In the past decade, intensive research has determined the role of proinflammatory cytokines in development of mucositis.
However, a large gap remains in the knowledge of the role of anti-inflammatory cytokines in the setting of chemotherapy-induced mucositis.
This critical paper will highlight current literature available relating to what is known regarding the development of mucositis, including the molecular mechanisms involved in inducing inflammation particularly with respect to the role of proinflammatory cytokines, as well as provide a detailed discussion of why it is essential to consider extensive research in the role of anti-inflammatory cytokines in chemotherapy-induced mucositis so that effective targeted treatment strategies can be developed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sultani, Masooma& Stringer, Andrea M.& Bowen, Joanne M.& Gibson, Rachel J.. 2012. Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475809
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sultani, Masooma…[et al.]. Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis. Chemotherapy Research and Practice No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-475809
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sultani, Masooma& Stringer, Andrea M.& Bowen, Joanne M.& Gibson, Rachel J.. Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475809
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475809
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر