Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis
Joint Authors
Sultani, Masooma
Stringer, Andrea M.
Bowen, Joanne M.
Gibson, Rachel J.
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
“Mucositis” is the clinical term used to describe ulceration and damage of the mucous membranes of the entire gastrointestinal tract (GIT) following cytotoxic cancer chemotherapy and radiation therapy common symptoms include abdominal pain, bloating, diarrhoea, vomiting, and constipation resulting in both a significant clinical and financial burden.
Chemotherapeutic drugs cause upregulation of stress response genes including NFκB, that in turn upregulate the production of proinflammatory cytokines such as interleukin-1β (IL-1β), Interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α).
These proinflammatory cytokines are responsible for initiating inflammation in response to tissue injury.
Anti-inflammatory cytokines and specific cytokine inhibitors are also released to limit the sustained or excessive inflammatory reactions.
In the past decade, intensive research has determined the role of proinflammatory cytokines in development of mucositis.
However, a large gap remains in the knowledge of the role of anti-inflammatory cytokines in the setting of chemotherapy-induced mucositis.
This critical paper will highlight current literature available relating to what is known regarding the development of mucositis, including the molecular mechanisms involved in inducing inflammation particularly with respect to the role of proinflammatory cytokines, as well as provide a detailed discussion of why it is essential to consider extensive research in the role of anti-inflammatory cytokines in chemotherapy-induced mucositis so that effective targeted treatment strategies can be developed.
American Psychological Association (APA)
Sultani, Masooma& Stringer, Andrea M.& Bowen, Joanne M.& Gibson, Rachel J.. 2012. Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475809
Modern Language Association (MLA)
Sultani, Masooma…[et al.]. Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis. Chemotherapy Research and Practice No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-475809
American Medical Association (AMA)
Sultani, Masooma& Stringer, Andrea M.& Bowen, Joanne M.& Gibson, Rachel J.. Anti-Inflammatory Cytokines : Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475809