Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance
المؤلفون المشاركون
Sadhukhan, Provash Chandra
Mukherjee, Anirban
Saha, Kallol
Firdaus, Rushna
Pal, Falguni
Chaudhuri, Sujit
Chandra, Alok
Konar, Asokananda
Biswas, Aritra
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Hepatitis C virus is the major cause of chronic hepatitis worldwide which finally leads to the development of hepatocellular carcinoma.
Toll like receptors (TLRs) play an important role in the course of many viral infections, but the role of TLRs in HCV pathogenesis has not been well elucidated so far.
Objective.
The aim of this study was to analyse the mRNA expression of TLRs 3, 7, and 8 in different stages of HCV infection including chronic, cirrhosis, interferon treated resolved, and relapsed cases.
Methodology.
Total RNA from whole blood was extracted and mRNA expression of TLRs 3, 7, and 8 genes was analyzed by quantitative real-time RT-PCR using β-Actin gene as an internal control.
Results.
This study consisted of 100 HCV infected individuals and twenty healthy controls.
TLR 3 expression was found to be significantly elevated in individuals who had spontaneously cleared the virus (p<0.001), whereas TLR 7 was found to be 3.26 times more elevated in patients with cirrhosis of liver.
In IFN induced individuals, TLR 8 expression levels were found to be 2.28-fold elevated as compared to control population.
Conclusion.
TLRs 3, 7, and 8 are prime biomarker candidates for HCV infection mRNA expression analysis which might improve current therapeutic approaches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Firdaus, Rushna& Biswas, Aritra& Saha, Kallol& Mukherjee, Anirban& Pal, Falguni& Chaudhuri, Sujit…[et al.]. 2014. Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475831
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Firdaus, Rushna…[et al.]. Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-475831
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Firdaus, Rushna& Biswas, Aritra& Saha, Kallol& Mukherjee, Anirban& Pal, Falguni& Chaudhuri, Sujit…[et al.]. Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475831
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475831
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر