Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance
Joint Authors
Sadhukhan, Provash Chandra
Mukherjee, Anirban
Saha, Kallol
Firdaus, Rushna
Pal, Falguni
Chaudhuri, Sujit
Chandra, Alok
Konar, Asokananda
Biswas, Aritra
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Hepatitis C virus is the major cause of chronic hepatitis worldwide which finally leads to the development of hepatocellular carcinoma.
Toll like receptors (TLRs) play an important role in the course of many viral infections, but the role of TLRs in HCV pathogenesis has not been well elucidated so far.
Objective.
The aim of this study was to analyse the mRNA expression of TLRs 3, 7, and 8 in different stages of HCV infection including chronic, cirrhosis, interferon treated resolved, and relapsed cases.
Methodology.
Total RNA from whole blood was extracted and mRNA expression of TLRs 3, 7, and 8 genes was analyzed by quantitative real-time RT-PCR using β-Actin gene as an internal control.
Results.
This study consisted of 100 HCV infected individuals and twenty healthy controls.
TLR 3 expression was found to be significantly elevated in individuals who had spontaneously cleared the virus (p<0.001), whereas TLR 7 was found to be 3.26 times more elevated in patients with cirrhosis of liver.
In IFN induced individuals, TLR 8 expression levels were found to be 2.28-fold elevated as compared to control population.
Conclusion.
TLRs 3, 7, and 8 are prime biomarker candidates for HCV infection mRNA expression analysis which might improve current therapeutic approaches.
American Psychological Association (APA)
Firdaus, Rushna& Biswas, Aritra& Saha, Kallol& Mukherjee, Anirban& Pal, Falguni& Chaudhuri, Sujit…[et al.]. 2014. Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475831
Modern Language Association (MLA)
Firdaus, Rushna…[et al.]. Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-475831
American Medical Association (AMA)
Firdaus, Rushna& Biswas, Aritra& Saha, Kallol& Mukherjee, Anirban& Pal, Falguni& Chaudhuri, Sujit…[et al.]. Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals : Potential Correlations of Pathogenesis and Spontaneous Clearance. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475831