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Tetracycline Effects on Candida Albicans Virulence Factors
المؤلفون المشاركون
McCool, Logan
Essmann, Michael
Mai, Hanh
Larsen, Bryan
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-05-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Object.
To determine if tetracycline, previously reported to increase the probability of developing symptomatic vaginal yeast infections, has a direct effect on Candida albicans growth or induction of virulent phenotypes.
Method.
In vitro, clinical isolates of yeast were cultivated with sublethal concentrations of tetracycline and yeast cell counts, hyphal formation, drug efflux pump activity, biofilm production, and hemolysin production were determined by previously reported methods.
Results.
Tetracycline concentrations above 150 μg/mL inhibited Candida albicans, but at submicrogram/mL, a modest growth increase during the early hours of the growth curve was observed.
Tetracycline did not inhibit hyphal formation at sublethal concentrations.
Hypha formation appeared augmented by exposure to tetracycline in the presence of chemically defined medium and especially in the presence of human serum.
Efflux pump CDR1 was upregulated and a nonsignificant trend toward increased biofilm formation was noted.
Conclusion.
Tetracycline appears to have a small growth enhancing effect and may influence virulence through augmentation of hypha formation, and a modest effect on drug efflux and biofilm formation, although tetracycline did not affect hemolysin.
It is not clear if the magnitude of the effect is sufficient to attribute vaginitis following tetracycline treatment to direct action of tetracycline on yeast.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McCool, Logan& Mai, Hanh& Essmann, Michael& Larsen, Bryan. 2008. Tetracycline Effects on Candida Albicans Virulence Factors. Infectious Diseases in Obstetrics and Gynecology،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-476058
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McCool, Logan…[et al.]. Tetracycline Effects on Candida Albicans Virulence Factors. Infectious Diseases in Obstetrics and Gynecology No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-476058
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McCool, Logan& Mai, Hanh& Essmann, Michael& Larsen, Bryan. Tetracycline Effects on Candida Albicans Virulence Factors. Infectious Diseases in Obstetrics and Gynecology. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-476058
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476058
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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